本发明公开了一种鱼类卵黄蛋白原基因及其编码蛋白与应用。其目的是提供一种鱼类卵黄蛋白原基因及其编码蛋白与其在检测鱼类生殖方面的疾病、调控鱼类生殖能力以及检测水生环境化学品毒性中的应用。该基因的CDNA是下述核苷酸序列之一:1)序列表中SEQ ID №:1的DNA序列;2)编码序列表中SEQ ID №:2的卵黄蛋白原的DNA序列;3)在高严谨条件下可与序列表中SEQ ID №:1限定的DNA序列杂交的核苷酸序列。
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