本发明属于生物技术领域，涉及干预EIF4H特定剪接亚型的干扰小RNA及(siRNA)反义寡聚核苷酸(ASO)序列成分以及检测EIF4H不同剪接亚型RNA及蛋白表达的方法。本发明提供的干预EIF4H剪接亚型表达的寡聚核苷酸序列为SEQ ID NO 6‑152，或与SEQ ID NO 6‑152中任意一项的序列重复超过5个核苷酸的干扰小RNA或者反义寡聚核苷酸，或者是其各种类似物、化学修饰形式或带有连接物的衍生核苷酸序列。本发明还提供了使用干预EIF4H剪接亚型表达的siRNA或者ASO在制备肿瘤治疗药物，及其在制备肿瘤诊断、治疗制品中的应用。
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