本发明涉及用于在具有或不具HIV共感染的免疫活性和免疫受损个体二者中诊断、监测和/或治疗结核病、监测个体对抗分枝杆菌化学疗法的响应、监测潜伏性结核病向活动性结核病的进展、区分活动性结核病与潜伏性结核病以及其它仿似结核病(TB)临床病况的生物标志。本发明还涉及用于使用所述生物标志诊断、监测和/或治疗结核病的方法。以上在所有方面适于以结核分枝杆菌为结核病致病微生物的肺和肺外结核分枝杆菌感染二者。因此本发明在协助未来对于结核病药物的发现工作中非常有用并且还提供代理临床终点(proxy clinical end points)以及成为对治疗的响应的有效预测器。
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[ DB ] CONNECT:[ UseTime:0.001356s ] mysql:host=pc-m5epcw1px949b110u.rwlb.rds.aliyuncs.com;port=3306;dbname=yousedb;charset=utf8
[ SQL ] SHOW COLUMNS FROM `tb_para` [ RunTime:0.001450s ]
[ SQL ] SELECT * FROM `tb_para` WHERE `id` = 1 LIMIT 1 [ RunTime:0.001137s ]
[ SQL ] SHOW COLUMNS FROM `tb_tech` [ RunTime:0.001143s ]
[ SQL ] UPDATE `tb_tech` SET `hit`=`hit`+1 WHERE `id` = 896779 [ RunTime:0.001215s ]
[ SQL ] SELECT * FROM `tb_tech` WHERE `id` = 896779 LIMIT 1 [ RunTime:0.000905s ]
[ SQL ] SHOW COLUMNS FROM `tb_admin` [ RunTime:0.001050s ]
[ SQL ] SELECT `realname` FROM `tb_admin` WHERE `id` = 1 LIMIT 1 [ RunTime:0.000799s ]
[ SQL ] SHOW COLUMNS FROM `tb_category` [ RunTime:0.000980s ]
[ SQL ] SELECT * FROM `tb_category` WHERE `id` = 147 LIMIT 1 [ RunTime:0.000716s ]
[ SQL ] SELECT * FROM `tb_category` WHERE `id` = 30 LIMIT 1 [ RunTime:0.000665s ]
[ SQL ] SHOW COLUMNS FROM `tb_anchor` [ RunTime:0.000968s ]
[ SQL ] SELECT * FROM `tb_anchor` ORDER BY `id` ASC [ RunTime:0.002405s ]
[ SQL ] SELECT `id`,`title` FROM `tb_tech` WHERE `id` > 896779 AND `check_status` = 1 AND `category_id` = 147 ORDER BY `submit_date` ASC LIMIT 1 [ RunTime:0.007963s ]
[ SQL ] SELECT `id`,`title` FROM `tb_tech` WHERE `id` < 896779 AND `check_status` = 1 AND `category_id` = 147 ORDER BY `submit_date` DESC LIMIT 1 [ RunTime:0.013159s ]
[ SQL ] select id,title,tag,submit_date from tb_tech where check_status=1 and id<>896779 order by submit_date desc limit 10 [ RunTime:0.004285s ]
[ SQL ] SHOW COLUMNS FROM `tb_mcc` [ RunTime:0.001113s ]
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[ SQL ] SHOW COLUMNS FROM `tb_industry_report` [ RunTime:0.001087s ]
[ SQL ] SELECT `id`,`cate_aid`,`cate_bid`,`title`,`pic`,`tag`,`price`,`hit`,`mode` FROM `tb_industry_report` [ RunTime:0.001227s ]
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